Teddi Mellencamp Asks for Advice on Handling the ’Severe Anxiety' From Immunotherapy amid Brain Cancer Struggle

Teddi Mellencamp, Instagram
Teddi Mellencamp asked for advice on how to deal with anxiety amid cancer treatment.Credit : 

Teddi Mellencamp/Instagram

NEED TO KNOW

  • Teddi Mellencamp asked fans for advice after sharing that she’s “full of anxiety” as she undergoes immunotherapy for stage 4 brain cancer
  • The Real Housewives of Beverly Hills alum, 44, said she gets anxiety “on random days for no apparent reason”
  • Commenters suggested adult coloring books and edibles, while others told her to check in with her doctor

Teddi Mellencamp reached out to fans for advice on how to handle the “severe anxiety” she’s experiencing amid treatment for stage 4 brain cancer. 

“OK, for those of y’all who have gone through immunotherapy, did you have severe anxiety?” the Real Housewives of Beverly Hills alum, 44, asked in a video she posted to Instagram on Aug. 14. While lying in bed in a taupe hoodie, the Two T’s in a Pod co-host shared “just on random days for no apparent reason like today I was able to walk."

Earlier in the day, she'd shared a video to her Instagram stories of her walk with son Cruz, 10; She also shares daughters Slate, 12, and Dove, 5, with estranged husband Edwin Arroyave, 

Afterwards, she shared, "I did the podcast, and now I'm just sitting here full of anxiety.”

“Is this common? What are things that you guys have done to help make you feel better.?” she asked, taking a deep breath. “Let me know. Looking for any positive advice. Thank you.”

The comments ranged from adult coloring books to edibles, supplements to breathing exercises, while others urged Mellencamp to get her labs checked as anxiety can be a symptom of another health issue.

Anxiety has been a recorded side effect from immunotherapy, with one study finding that as treatment increased, more than half of the participants had anxiety.

Teddi Mellencamp Arroyave arrives at the Alliance for Women in Media Foundation's 50th annual Gracie Awards Gala at Beverly Wilshire, A Four Seasons Hotel on May 20, 2025 in Beverly Hills, California.
Teddi Mellencamp in Beverly Hills in May 2025.

Maya Dehlin Spach/FilmMagic

The reality star — who has been documenting her ongoing melanoma diagnosis after undergoing 17 surgeries for the invasive skin cancer — confirmed in April that her disease progressed to stage 4, having metastasized to her brain and lungs. She needed immunotherapy, radiation and surgery to treat the tumors.